Dextran sulfate sodium-induced inflammation and colitis in mice are ameliorated by (R)-ketamine, but not (S)-ketamine: A role of TrkB signaling

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that causes long-lasting inflammation and in the gastrointestinal tract. Depression common symptom patients with UC. (R)-ketamine new safer antidepressant than (R,S)-ketamine (S)-ketamine. Here, we examined effects of two ketamine enantiomers on dextran sulfate sodium (DSS)-induced model Ingestion 3% DSS drinking water for 14 days increased scores Disease Activity Index (DAI) mice. Repeated administration (10 mg/kg/day, or last 7 days), but not (S)-ketamine significantly ameliorated DAI score blood levels interleukin-6 (IL-6) DSS-treated In addition, (R)-ketamine, (S)-ketamine, attenuated reduced colonic length Furthermore, DSS-induced IL-6 were after subsequent repeated mg/kg/day 5-aminosalicyclic acid (50 days). Moreover, pretreatment tropomyosin-receptor-kinase B (TrkB) antagonist ANA-12 (0.5 mg/kg) blocked beneficial UC model. The study shows can produce through TrkB stimulation. Therefore, may be novel therapeutic drug diseases such as